01
CryoSieve
Particle sorting and sieving for single-particle cryo-EM. CryoSieve helps remove unnecessary particles from final stacks so reconstruction quality can improve.
Cryo-EM workflow copilot
CoCo weaves additional modules straight into the cryo-EM workflow.
CoCo acts as a copilot for your cryo-EM workflow, integrating CryoSieve, CryoPROS, and CTFA directly into the process you already run.
- Interface
- Graphical user interface
- Role
- Cryo-EM workflow copilot
- Modules
- 3 capabilities in one hub
- Workflow
- Integrates into current cryo-EM workflows
Wrapped modules
Three capabilities, one CoCo workbench.
02
CryoPROS
A preferred-orientation correction framework for single-particle cryo-EM, using AI-generated auxiliary particles and co-refinement.
03
CTFA
Reserved for the CTFA module. It appears in the CoCo system model as a planned capability and is marked TBD until public details are ready.
Primary action
One download. Three capabilities.
CoCo is the only download target on this page. CryoSieve, CryoPROS, and CTFA are accessed through CoCo, not as standalone downloads.
Public CoCo installer link pending.
- Use CoCo as the central GUI interface.
- Access CryoSieve and CryoPROS as wrapped analysis modules.
- Track CTFA as TBD until its release details are available.
Code & Publications
Code and publications for CryoSieve and CryoPROS.
Code
Publications
CryoSieve
"A minority of final stacks yields superior amplitude in single-particle cryo-EM"
Nature Communications, 2023If CryoSieve contributes to your work, please cite the paper above. Full demo datasets and expected results are available at cryosieve-demos.
CryoPROS
"CryoPROS: Correcting misalignment caused by preferred orientation using AI-generated auxiliary particles"
Nature Communications, 2025If CryoPROS contributes to your work, please cite the paper above.
